Chemoprevention

Hennekens Ch.H., Buring J.E., Manson J.E., Stamper M., Rosner B., Cook N., Belanger Ch., La Motte F., Gasiano J.M. et al. Lack of effect on long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular diseases. New Engl.J. med., 1996, 334, 1145-9.

Lee I.-Min, Cook N., Manson J.E., Hennekens H. Beta carotene supplementation and incidence of cancer and cardiovascular disease: The Women's Health study.J.Natl. Cancer Inst., 1999, 91, 2102-6.

The Alpha-Tocopherol, Beta Carotene Prevention Study Group. The effect of vitamin E and beta carotrne on the incidence of lung cancer and other cancers in male smoker. New Engl.J.Med., 1994, 330, 1029-1035.

Omen G.S., Goodman G.E., Thornquist M.D., Balmes J., Cullen M.R., Glass A., Keogh J.P. et al. Effect of combination of beta carotene and vitamin A on lung cancer and cardiovascular diseases. N.Engl. J. Med., 1996, 334, 1150-5.

Blot W.J.,, Li J.Y., Taylor P.R., Guo W., Dawsey S., Wang G.Q., Yang C.S.,Zheng S.F., Gail M., and Li G.Y. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence , and disease-specific mortality in the general population. J Natl. Cancer Inst., 1993, 85, 1483-1492.

Correa p., Fonthan E.T.H., Bravo J.C., Bravo L.E., Ruiz B., Zarama G., Realpe J.L., Malcolm G.T., Li D., Johnson W.D. and Mera R. Chemoprevention of gastric dysplasia: Randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy.
J Natl cancer Inst., 2000, 92. 1881-8.

Clark L.C., Combs G.F., Turnbull B.W., Slate E.H., Chalker D.K., Chow J. et al Effects of selenium supplementation for cancer prevention in patients with carcinoma of of the skin. A randomized controlled trial. Nutrition Prevention of Cancer Study Group. JAMA 1996, 276, 1957-63.

Li J.Y.,Taylor P.R., Li B., Dawsey S., Wang G.Q., Ershow A.G. et al. Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. J natl Cancer Inst, 1993, 85, 1492-8.

Mac Keown-Eissen G.E., Bright-See E., Bruice W.R., Jasmani V. and The Toronto Polyp prevention Group. A randomized trial of a low fat high fibre diet in the recurrence of colorectal polyps. J Clin Epidemiol., 1994, 47, 525-536.

Schatzkin A., Lanza E., Corle D., Lance P., Iber F., Caan B., Shike M, et al. Lack of effect of a low-fat, high-fibre diet on the recurrence of colorectal adenomas. New Engl J Med, 2000, 342, 1149-55.

Mac Lennan R., Macrae F., Bain Ch., Battistutta D., Chapius P., Gratten H., Lambert J et al. Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. J Natl Cancer Inst 1995, 87, 1760-6.

Alberts D.S., Martinez M.E., Roe D.J., Guillen-Rodrigues J.M., Marshall J.R.,
Van Leuven J.B., Reid M.E., Ritenbaugh C., Vargas P.A. et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. New Engl J.Med., 2000, 342, 1156-62.

Bonithon-Kopp c., Kronborg O., Giacosa A., Rath U., Faivre J., for European Cancer Prevention Organisation Study group. Calcium and Fibre supplementation in prevention of colorectal adenoma recurrence: arandomised intervention study. Lancet, 2000, 356, 1300-06.

Baron J.A., Beach M., Mandel J.S., Van Stock R.U., Haile R.W., Sandler R.S., Rothstein R., Summers R.W., Snover D.C. et al. For the Calcium Polyp Study Group. Calcium supplements for the prevention of colorectal adenomas. New Engl J Med, 1999, 340, 101-7.

Thun M.J., Henley J. and Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J Natl cancer inst, 2002, 94, 252-66.

Cuzick J., Powels T., Veronesi U., Forbes J., Edwards R., Ashley S., and Boyle P. Overview of the main outcomes in breast cancer prevention trials. Lancet (in press)